Karkhana is a part of Secunderabad, near Hyderabad. It is under the Trimulgherry suburb and is 4 kilometres from the Secunderabad station. The Rajiv Gandhi International Airport is around 38.2 kilometres and can be reached through Hyderabad Elevated Expressways. The Jubilee Bus Stand is only 1 kilometres from here. Karkhana real estate has recently witnessed a boom and is a hub of several IT start-ups.

There are several micro markets located in Karkhana such as Venkat Ram Nagar, AP Textbook Colony, State Bank Colony, R&D Defence Colony, Vasavi Nagar and Gunrock Enclave.

TSRTC buses are available from here that connect it to various parts of Hyderabad and Secunderabad. The first phase plan of the Hyderabad Metro Railway has a station for this area. The nearest MMTS Railway Station is in Safilguda and Ramakistapuram Gate Railway station.

Several prominent developers are working on property in Karkhana, including Amsri. The area has apartment enclaves that offer 2 and 3 BHK flats. Karkhana property has been rated 8.5 out of 10 for the social infrastructure available in the vicinity.

Schools such as Adarsh Convent High School, CVP Model High School, St Joseph High School, Faust High School, Sacred Heart School and Wesley Girls High School are located in the vicinity. Sowmya Multi Specialty Hospital, Rainbow Hospital Parvathi Nursing Home, Sairam Multispecialty Hospital and Nest Children Hospital are popular healthcare centres in the vicinity.